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Flow Cytometry Analysis of Immune Cells Within Murine Aortas
Published on: July 1, 2011
Adaptive T cell immune responses and atherogenesis
Soraya Taleb1, Alain Tedgui, Ziad Mallat
1Inserm U970, Paris Cardiovascular Research Center, 56, rue Leblanc, 75015 Paris, France.
Current Opinion in Pharmacology
|March 9, 2010
Summary
This review explores the roles of T helper 1 (Th1), T helper 2 (Th2), regulatory T cells, and interleukin-17-producing T cells (Th17) in atherosclerosis, a chronic inflammatory arterial disease.
Area of Science:
- Immunology
- Cardiovascular Medicine
- Inflammation
Background:
- Atherosclerosis is a chronic inflammatory arterial disease.
- Immune responses, including T helper cell subsets, are critical in its development.
- Regulatory T cells show protective effects, while Th17 cells' role is under investigation.
Purpose of the Study:
- To review current knowledge on effector and regulatory T cell responses in atherosclerosis.
- To discuss the specific contribution of Th17 cells to the disease process.
Main Methods:
- Literature review of existing studies on T cell subsets in atherosclerosis.
- Analysis of the roles of Th1, Th2, regulatory T cells, and Th17 cells.
Main Results:
- Th1 and Th2 responses have been studied, with regulatory T cells showing a protective role.
- Interleukin-17-producing T cells (Th17) represent a distinct lineage with significant implications in autoimmune diseases.
Conclusions:
- T cell subsets, including Th17, play a complex role in atherosclerosis.
- Further research is needed to fully elucidate the contribution of Th17 cells to atherosclerosis pathogenesis.
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