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Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan using a One-pot, Two-step Protocol
Published on: September 21, 2021
[Tryptophan metabolism: a key player in cardiometabolic diseases]
Mouna Chajadine1, Ludivine Laurans1, Soraya Taleb1
1Université Paris Cité, Inserm U970, Centre de recherche cardiovasculaire (PARCC), Hôpital européen Georges Pompidou, Paris, France.
Abstract:
Tryptophan (Trp), an essential amino acid, plays a central role in metabolism, inflammation, immunity, and energy homeostasis. It is primarily metabolized through the kynurenine, indole, and serotonin pathways, generating metabolites with either protective or harmful effects depending on the physiological and tissue context. Dysregulation of these pathways contributes to obesity, diabetes, and cardiovascular diseases. Understanding these mechanisms paves the way for personalized nutritional and therapeutic strategies to prevent and manage cardiometabolic diseases.
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