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McNemar's Test

McNemar's Test

McNemar's Test is a nonparametric statistical test used to determine if there is a significant difference in proportions between two related groups when the outcome is binary (e.g., yes/no, success/failure). It is beneficial when we have paired data, such as pre-test/post-test designs, where the same subjects are measured under two different conditions. The test is named after the statistician Quinn McNemar, who introduced it in 1947. It is commonly used in situations where subjects are...

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Mismatch Negativity (MMN) response studies in elderly subjects.

Gabriela Buranelli¹, Marcella Brito Barbosa, Cristiane Fregonesi Dutra Garcia

¹University of Franca, Franca/SP.

Brazilian Journal of Otorhinolaryngology

|March 9, 2010

Summary

Mismatch Negativity (MMN) responses in elderly individuals show no significant differences in latency or amplitude compared to younger adults. This auditory evoked potential study found no gender or hemispheric variations in the elderly group.

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Area of Science:

Neuroscience
Audiology
Gerontology

Background:

Mismatch Negativity (MMN) is an endogenous auditory evoked potential reflecting auditory processing.
Understanding MMN changes with aging is crucial for assessing auditory function in the elderly.

Purpose of the Study:

To characterize MMN responses in elderly subjects.
To compare MMN responses between elderly and adult subjects.

Main Methods:

A prospective study of 30 elderly subjects (60-80 years old).
Included medical evaluation, audiometry, immittance tests, otoacoustic emissions, and MMN recordings.
Mann-Whitney statistical test was employed.

Main Results:

Mean MMN latency in women: 148.67-161.33 ms; in men: 159.07-171 ms.
Mean MMN amplitude in women: -2.177 to -2.753 µV; in men: -1.847 to -1.953 µV.
No significant differences in latency or amplitude were found between genders or hemispheres in the elderly.

Conclusions:

Elderly subjects exhibit MMN responses comparable to younger adults.
No statistically significant differences were observed in MMN latency or amplitude based on gender, hemispheric side, or age group comparison.
MMN appears robust across genders and hemispheres in the elderly population.