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Thyroid hormone changes in early kidney transplantation and its correlation with delayed graft function.
Reza Hekmat1, Zahra Javadi, Malihe Layghian Javan
1Department of Nephrology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. drhekmatreza@yahoo.com
Urology Journal
|March 9, 2010
Summary
Thyroid hormone levels (T3 and T4) decrease after kidney transplants. This reduction is more pronounced in patients experiencing delayed graft function (DGF), suggesting it is a consequence of DGF, not a cause.
Area of Science:
- Nephrology
- Endocrinology
- Transplantation Medicine
Background:
- Thyroid hormones (T3, T4) influence kidney function.
- Kidney function changes can impact thyroid hormone levels.
- The relationship between thyroid hormones and kidney transplant outcomes requires investigation.
Purpose of the Study:
- To evaluate early changes in serum triiodothyronine (T3), thyroxin (T4), and thyroid-stimulating hormone (TSH) after kidney transplantation.
- To determine the association between these thyroid hormone changes and delayed graft function (DGF).
Main Methods:
- Serum T3, T4, and TSH levels were measured in 55 kidney transplant recipients before and up to 21 days post-transplant.
- Thyroid hormone levels were compared between patients with normal graft function and those with DGF.
Main Results:
- Serum T3 and T4 levels significantly decreased early after kidney transplantation.
- Patients with DGF exhibited a more pronounced reduction in T3 and T4 levels compared to those with normal graft function.
- The greater reduction in thyroid hormones persisted for up to two weeks in DGF patients.
Conclusions:
- Early post-kidney transplant, both T3 and T4 levels decline.
- The significant reduction in thyroid hormones is more prominent in patients with DGF.
- These findings support the concept of sick euthyroid syndrome as a consequence, not a cause, of DGF.
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