[Association of HLA alleles with pathological parameters in breast cancer]

The study included 67 breast cancer patients and 147 healthy controls--residents of the city of Novosibirsk. HLA association with tumor cell differentiation pattern and grade was established in breast cancer patients. -A19, -B27, -DR1, -DR6 (p < or = 0.01) and -A1, -A2, -B12, -B35, -B40 (p < or = 0.05) were shown to be associated with disease while -DR3, -DR4 and -B15--with resistance to it. Absence of metastasis to the lymph nodes was associated with -B16 and -B35, and -A19/DR2, -B35/DR1: local metastases -B40 in combination with -A1, -A10, -DR2 and A10/DR2; metastases to the regional lymph nodes--with -B5, -B17 and phenotypes-- -A2/B5, -B5/B18. Well differentiated cell tumors were associated with -A3, -A19, -B7, -B12, -B-35 in combination with -DR1, -DR2, -DR5 and phenotypes-- -A3/A19 and -A1/B35; moderately-- -B40 and -DR1; phenotypes-- -A1/B40, -B27/DR1, -B40/DR1; poorly differentiated cell tumor-- -A19, -DR6 and -A2/-A19, -A9/DR6, -B40//DR6. HLA testing may be instrumental as an additional means of prognosis for beast cancer.