Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clomipramine for obsessive-compulsive disorder.

M Feinberg1

  • 1Department of Mental Health Sciences, Hahnemann University School of Medicine, Philadelphia, Pennsylvania.

American Family Physician
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A qualitative study of adaptation challenges of Ukrainian refugees in the United States.

Children and youth services review·2025
Same author

Factors associated with recent unsuppressed viral load in HIV-1-infected patients in care on first-line antiretroviral therapy in South Africa.

International journal of STD & AIDS·2018
Same author

Sources of bias in Gorman critique of bias: again a need for more reasonable, valid conclusions with true dialogue.

Psychological medicine·2017
Same author

Preference of certain scolytidae for different conifers : A statistical approach.

Journal of chemical ecology·2014
Same author

Psychopathology and pathological gambling among males: Theoretical and clinical concerns.

Journal of gambling studies·2013
Same author

Rationale and methods of the European Food Consumption Validation (EFCOVAL) Project.

European journal of clinical nutrition·2011

Clomipramine is a key medication for obsessive-compulsive disorder (OCD), impacting serotonin transmission. While effective, potential side effects like seizures exist, prompting research into alternative antidepressants for OCD treatment.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Psychiatry

Background:

  • Obsessive-compulsive disorder (OCD) is a prevalent and disabling condition affecting approximately 2% of the U.S. population.
  • Clomipramine is the sole FDA-approved medication for OCD treatment, demonstrating unique efficacy among tricyclic antidepressants.
  • Its therapeutic action is linked to potent effects on serotonergic neurotransmission.

Purpose of the Study:

  • To review the efficacy and tolerability of clomipramine in treating obsessive-compulsive disorder.
  • To discuss the pharmacological profile of clomipramine, particularly its serotonergic activity.
  • To explore emerging research on alternative serotonergic antidepressants for OCD.

Main Methods:

  • Review of existing clinical data and pharmacological studies on clomipramine.

Related Experiment Videos

  • Analysis of comparative efficacy and side effect profiles of different antidepressant classes.
  • Examination of ongoing controlled studies for novel OCD treatments.

    • Main Results:

    • Clomipramine exhibits significant efficacy in OCD treatment, despite numerous anticholinergic effects.
    • A notable side effect is a 0.4% incidence of seizures.
    • Emerging evidence suggests other selective serotonin reuptake inhibitors (SSRIs) may offer comparable efficacy with potentially better tolerability.

    Conclusions:

    • Clomipramine remains a vital, though not risk-free, treatment for OCD.
    • The unique efficacy of clomipramine highlights the importance of serotonergic pathways in OCD.
    • Further research into selective serotonergic antidepressants is crucial for expanding OCD treatment options.