Effect of NlpE overproduction on multidrug resistance in Escherichia coli
Kunihiko Nishino1, Seiji Yamasaki, Mitsuko Hayashi-Nishino
1Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan. nishino@sanken.osaka-u.ac.jp
Antimicrobial Agents and Chemotherapy
|March 10, 2010
Abstract:
NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps in Escherichia coli.
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