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Peri-insular hemispherotomy in children: a single institution experience
D Scavarda1, V Imada, A C Rolland
1Department of Pediatric Neurosurgery, Hôpital des Enfants La Timone, Marseille, France. didier.scavarda@ap-hm.fr
Insights
Peri-insular hemispherotomy is a safe and effective surgical option for children with refractory hemispheric epilepsy, achieving seizure freedom in 72% of cases with no complications. This procedure is particularly successful for acquired pathologies.
Area of Science:
- Neurosurgery
- Pediatric Neurology
- Epileptology
Background:
- Refractory hemispheric epilepsy in children poses significant challenges to treatment.
- Hemispheric surgeries have evolved, with peri-insular hemispherotomy emerging as a key intervention.
- Evaluating surgical outcomes is crucial for optimizing patient care.
Purpose of the Study:
- To assess the efficacy and safety of peri-insular hemispherotomy in pediatric patients.
- To compare surgical outcomes with existing medical literature.
- To analyze factors influencing surgical success.
Main Methods:
- Retrospective chart review of 14 children undergoing peri-insular hemispherotomy (1993-2007).
- Analysis of epilepsy onset, imaging, etiology, EEG, seizure types, antiepileptic drugs (AEDs), and neuropsychological data.
- Evaluation of seizure control and complications post-surgery.
Main Results:
- 14 children (9 male, 5 female) with refractory hemispheric epilepsy were included.
- Mean age at onset was 16 months; mean age at surgery was 8.4 years.
- 10 children (72%) achieved seizure freedom with no surgical complications; acquired pathologies showed better outcomes than developmental ones.
Conclusions:
- Peri-insular hemispherotomy is a safe and highly effective treatment for refractory hemispheric epilepsy in children.
- The procedure's success is closely linked to the interplay between pathology and surgical technique.
- Acquired pathologies demonstrate superior results compared to developmental etiologies.
Abstract:
The objective of this paper is to evaluate our experience in performing peri-insular hemispherotomy in refractory epileptic children. First, we address the history of hemispheric surgeries for epilepsy and then we compare our results to the medical literature in term of seizure control and complications. Between 1993 and 2007, 14 children who suffered from refractory hemispheric epilepsy underwent a peri-insular hemispherotomy. All children's charts were reviewed in a retrospective manner. Age at onset of epilepsy, imaging studies, cause of refractory epilepsy, electroencephalography findings, type of epileptic seizure, number of antiepileptic drugs (AED), preoperative neuropsychological evaluation and surgical outcome with regard to the children's seizure activity were analyzed. Nine boys and 5 girls were enrolled in this study. The mean age at onset of epilepsy was 16 months (range birth-5 years). All the children presented complex partiel seizures. Seizure frequency varied from 5 to 100 a day. The average delay prior to the hemispherotomy was 83 months (range 12-226 months). Mean age at the time of the surgery was 8.4 years (range 1.7-18 years). We performed 9 peri-insular hemispherotomies on the right side and 5 on the left. There were no reported surgical complications in this series. 10 children are seizure free (72%). Peri-insular hemispherotomy must be considered as a safe and very efficient therapeutic approach for children suffering from hemispheric refractory epilepsy. Peri-insular hemispherotomies are procedures where pathology and surgical technique interact narrowly. Acquired pathologies had better results than developmental ones.
