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Related Experiment Video

Updated: Jun 15, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

Is there a role for immunotherapy in osteosarcoma?

¹Oncology and Pediatrics, Musculoskeletal Tumor Program, Johns Hopkins University, Bunting-Blaustein Cancer Research Building, Room 2M51, 1650 Orleans St, Baltimore, MD 21231, USA. LOEBDA@jhmi.edu

Cancer Treatment and Research

|March 10, 2010

Summary

Systemic chemotherapy has significantly improved osteosarcoma survival, but outcomes for metastatic disease remain poor. Immunotherapy is being explored as a promising multi-modality treatment for osteosarcoma.

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Last Updated: Jun 15, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

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Published on: March 18, 2014

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Area of Science:

Oncology
Immunology
Orthopedic Oncology

Background:

Osteosarcoma prognosis dramatically improved with systemic chemotherapy introduction.
Survival rates pre-1975 were poor (5-20%), with most patients developing pulmonary metastases.
Chemotherapy improved localized disease outcomes but not metastatic disease survival.

Purpose of the Study:

To review historical and current immunotherapy approaches for osteosarcoma.
To highlight the potential role of immunotherapy in multi-modality treatment strategies.
To explore advancements in harnessing the immune system for osteosarcoma treatment.

Main Methods:

Review of historical and contemporary immunotherapy strategies.
Analysis of treatment outcomes for localized and metastatic osteosarcoma.
Examination of multi-modality treatment paradigms incorporating immunotherapy.

Main Results:

Chemotherapy significantly improved survival for localized osteosarcoma.
Little improvement in outcomes for metastatic osteosarcoma since the mid-1980s.
Early immunotherapy attempts had limited success, but newer approaches show promise.

Conclusions:

Immunotherapy represents a potential advancement in osteosarcoma treatment.
Further investigation into immunotherapy's role in multi-modality therapy is warranted.
Harnessing the immune system may offer new hope for osteosarcoma patients, particularly those with metastatic disease.