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A small interference RNA screen revealed proteasome inhibition as strategy for glioblastoma therapy

Kimberly Ng1, Masayuki Nitta, Lauren Hu

  • 1Deaprtment of Radiation Oncology, Dana Farber Cancer Institute Boston, Massachusetts, USA.

Clinical Neurosurgery
|March 11, 2010
PubMed
Abstract

No abstract available in PubMed .

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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