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Updated: Jun 15, 2026

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
Published on: March 11, 2017
Adsorption of carbamazepine onto crospovidone to prevent drug recrystallization
Martin Schulz1, Bernhard Fussnegger, Roland Bodmeier
1College of Pharmacy, Freie Universität Berlin, Kelchstrasse 31, 12169 Berlin, Germany.
Abstract:
The adsorption mechanism of the poorly water-soluble drug carbamazepine onto crosslinked polyvinylpyrrolidone (crospovidone) was investigated by adsorption isotherms in different solvents and Fourier-transformation infrared spectroscopy (FTIR). The drug adsorption was a result of hydrogen bonds between carbamazepine's amine group and crospovidone's carbonyl group. Solvents with a hydrogen donor site competed with the drug for binding sites on crospovidone and thereby decreased the extent of drug adsorption. To optimize the drug-carrier ratio, adsorbates with different drug loadings were prepared by the solvent deposition method and analyzed for drug crystals using differential scanning calorimetry, X-ray diffraction, scanning electron microscopy and polarized light microscopy. Adsorbates with a drug loading of 9.1% or less did not show drug crystals. The drug release increased in the order of micronized drug
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