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Related Experiment Video

Updated: Jun 15, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

Socially induced morphine pseudosensitization in adolescent mice.

Stephen R Hodgson1, Rebecca S Hofford, Kris W Roberts

  • 1Behavioral and Cellular Neuroscience, Department of Psychology, Texas A&M University, College Station, Texas 77843, USA.

Behavioural Pharmacology
|March 11, 2010
PubMed
Summary

Adolescent mice exposed to social cues from morphine-treated peers showed increased activity, unlike adults. This highlights adolescents' heightened vulnerability to social influences on drug responses.

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pharmacology

Background:

  • Social influences significantly predict adolescent drug use.
  • Understanding social effects on drug response is crucial for public health.
  • Adolescent brains are uniquely sensitive to environmental and social factors.

Purpose of the Study:

  • To investigate the impact of social interaction on morphine-induced hyperlocomotion in adolescent and adult mice.
  • To determine if social exposure can induce a sensitization-like response to morphine in adolescents.
  • To compare the effects of social context on drug response between adolescent and adult rodents.

Main Methods:

  • Three groups of adolescent and adult male mice were used: morphine-treated, saline cage-mates, and saline alone.

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  • Mice received daily subcutaneous injections of morphine or saline over a treatment period.
  • Locomotor activity was assessed individually after a final morphine challenge dose.

    • Main Results:

    • Adolescent saline cage-mates exhibited enhanced hyperlocomotion to morphine, mimicking locomotor sensitization.
    • Adult saline cage-mates did not show significant differences in morphine response compared to saline alone controls.
    • Both morphine-treated adolescents and adults developed locomotor sensitization, as expected.

    Conclusions:

    • Adolescent mice display a significant vulnerability to social influences regarding drug-induced locomotor activity.
    • This social influence effect on drug response is specific to the adolescent period and not observed in adults.
    • Findings suggest that social context plays a critical role in shaping adolescent responses to drugs of abuse.