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Updated: Mar 29, 2026

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Brewed Coffee and Its Components Act Through Orphan Nuclear Receptor 4A1 (NR4A1)

Amanuel Hailemariam1, Srijana Upadhyay1, Arafat Rahman Oany1

  • 1Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, USA.

Nutrients
|March 28, 2026
PubMed
Summary

Brewed coffee and its polyphenols bind to orphan nuclear receptor 4A1 (NR4A1), suggesting NR4A1 mediates coffee's health benefits and role in aging. This research highlights coffee's compounds as NR4A1 ligands.

Keywords:
NR4A1coffee extractspolyphenolicsreceptor binding

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