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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
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Morphogenesis02:19

Morphogenesis

Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.

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A Method for Labeling Vasculature in Embryonic Mice
09:58

A Method for Labeling Vasculature in Embryonic Mice

Published on: October 7, 2011

Signaling circuitry in vascular morphogenesis.

Carmen M Warren1, M Luisa Iruela-Arispe

  • 1Department of Molecular, Cellular, and Developmental Biology, University of California Los Angeles, Los Angeles, California, USA.

Current Opinion in Hematology
|March 11, 2010
PubMed
Summary
This summary is machine-generated.

Recent breakthroughs in growth factor signaling reveal new insights into blood vessel formation (angiogenesis). Understanding cell biology and interactions is key to regulating this complex process.

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Last Updated: Jun 15, 2026

A Method for Labeling Vasculature in Embryonic Mice
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Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
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Directed Differentiation of Hemogenic Endothelial Cells from Human Pluripotent Stem Cells
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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Physiology

Background:

  • Vascular morphogenesis is a complex process involving coordinated cellular activities.
  • Growth factors and morphogens play critical roles in regulating blood vessel formation.

Purpose of the Study:

  • To review recent breakthroughs in growth factor signaling.
  • To highlight conceptual changes in understanding blood vessel formation.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of studies on vascular morphogenesis.
  • Focus on cell biology and signaling pathways.

Main Results:

  • Characterization of cell types in vascular sprouts.
  • Elucidation of cell-cell and cell-matrix interactions in signaling.
  • Identification of novel roles for vascular endothelial growth factor in cell survival and metabolism.

Conclusions:

  • Blood vessel sprouting requires coordinated cellular response to growth factors and morphogens.
  • Cell surface receptors and intracellular cascades initiate migration and proliferation.
  • Contextual factors, including cell-cell and cell-matrix interactions, significantly influence endothelial cell responses to growth factors.