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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Related Experiment Video

Updated: Jun 15, 2026

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Hydrodynamic delivery protocols.

Piotr G Rychahou1, B Mark Evers

  • 1Department of Surgery, The University of Texas Medical Branch, Galveston, TX, USA.

Methods in Molecular Biology (Clifton, N.J.)
|March 11, 2010
PubMed
Summary
This summary is machine-generated.

Hydrodynamic administration offers a safe and effective method for delivering small interfering RNAs (siRNAs) to silence disease-causing genes. This technique enables transient gene knockdown for potential therapeutic applications.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Gene Therapy

Background:

  • RNA interference (RNAi) is a promising therapeutic strategy for silencing disease-causing genes.
  • Effective delivery of small interfering RNAs (siRNAs) to target tissues remains a significant challenge for RNAi-based therapies.
  • Current in vivo RNAi methods include viral vectors and high-volume intravenous injections, each with limitations.

Purpose of the Study:

  • To evaluate hydrodynamic administration as a method for delivering naked siRNA constructs in vivo.
  • To demonstrate the feasibility of transient gene knockdown using this delivery technique.
  • To assess the potential of RNAi for silencing endogenous disease-related genes with a clinically acceptable approach.

Main Methods:

  • Hydrodynamic administration was used to deliver naked siRNA constructs into experimental animals.
  • The technique focuses on direct delivery of active siRNAs, bypassing viral vectors.
  • The study aimed for transient gene knockdown of endogenous genes.

Main Results:

  • Hydrodynamic administration successfully delivered naked siRNA constructs into target tissues.
  • Transient gene knockdown of endogenous genes was achieved.
  • The method demonstrated the potential for RNAi-based gene silencing in a disease context.

Conclusions:

  • Hydrodynamic administration is a viable and safe technique for delivering siRNAs in vivo.
  • This approach facilitates transient gene knockdown, offering a promising route for RNAi therapeutics.
  • Direct siRNA delivery via hydrodynamic administration presents a clinically relevant strategy for treating genetic diseases.