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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates
08:07

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Published on: June 17, 2016

Controlling stem cell fate with material design.

Ross A Marklein1, Jason A Burdick

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.

Advanced Materials (Deerfield Beach, Fla.)
|March 11, 2010
PubMed
Summary
This summary is machine-generated.

New biomaterials guide stem cell behavior for tissue regeneration. These advanced materials offer chemical, mechanical, and structural cues to control cell development and matrix formation, improving cell expansion and tissue engineering applications.

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Patterning of Embryonic Stem Cells Using the Bio Flip Chip
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Patterning of Embryonic Stem Cells Using the Bio Flip Chip

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Related Experiment Videos

Last Updated: Jun 15, 2026

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates
08:07

Stencil Micropatterning of Human Pluripotent Stem Cells for Probing Spatial Organization of Differentiation Fates

Published on: June 17, 2016

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
10:04

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

Published on: September 28, 2019

Patterning of Embryonic Stem Cells Using the Bio Flip Chip
05:25

Patterning of Embryonic Stem Cells Using the Bio Flip Chip

Published on: October 1, 2007

Area of Science:

  • Biomaterials Science
  • Stem Cell Biology
  • Tissue Engineering

Background:

  • Stem cell behavior is heavily influenced by their microenvironment.
  • Understanding these interactions is crucial for regenerative medicine.
  • Materials science offers novel ways to control stem cell fate.

Purpose of the Study:

  • To review recent advances in materials-based approaches for stem cell manipulation.
  • To cover fundamental concepts of material-stem cell interactions.
  • To highlight applications in cellular culture and tissue regeneration.

Main Methods:

  • Review of current literature on biomaterials and stem cell research.
  • Analysis of how material properties (chemistry, mechanics, structure, molecule delivery) influence stem cells.
  • Discussion of advancements in stem cell expansion and scaffolding techniques.

Main Results:

  • Materials can precisely control stem cell fate decisions.
  • Biomaterials facilitate stem cell-derived matrix formation.
  • Advanced materials improve stem cell expansion and scaffolding for tissue regeneration.

Conclusions:

  • Materials science is pivotal in advancing stem cell applications.
  • Biomaterial-driven control of stem cells enhances tissue engineering efficacy.
  • Continued development of materials will accelerate clinical translation in regenerative medicine.