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Updated: Jun 15, 2026
05:49
Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
[Antiphospholipid syndrome: much new data].
Philippe de Moerloose1, Yordanka Tirefort-Dimitrova, Franziska Noger
1Unité d'hémostase, HUG, Genève. philippe.demoerloose@hcuge.ch
Revue Medicale Suisse
|March 12, 2010
Summary
Recent advancements clarify antiphospholipid syndrome (APS) diagnostic tests and pathophysiology, emphasizing complement and genetic factors. New data from large cohorts and registries inform clinical aspects and treatment algorithms for APS.
Area of Science:
- Immunology and Rheumatology: Focuses on antiphospholipid syndrome (APS), a complex autoimmune disorder.
- Diagnostic marker refinement for antiphospholipid syndrome (APS).
- Pathophysiology of antiphospholipid syndrome (APS), including complement system and genetic predisposition.
Context:
- Antiphospholipid syndrome (APS) diagnosis and management have evolved with new research.
- Existing diagnostic criteria and understanding of APS pathophysiology are being updated.
- Need for precise diagnostic tools and understanding of APS mechanisms.
Purpose:
- To review and synthesize recent key findings on antiphospholipid syndrome (APS).
- To clarify diagnostic approaches, including lupus anticoagulant and antiphospholipid antibodies.
- To update understanding of APS pathophysiology and propose treatment algorithms.
Summary:
- Refined diagnostic tests for antiphospholipid syndrome (APS), including modified anti-beta2-glycoprotein I assays, improve specificity.
- Anticardiolipin antibodies remain crucial for pregnancy morbidity but may not be necessary for thrombosis diagnosis in APS.
- New insights highlight the role of complement activation and genetic predisposition in APS pathophysiology.
- Prospective European cohort data and registries (e.g., pediatric and catastrophic APS) provide critical clinical information.
- Proposed treatment algorithms for managing patients with antiphospholipid syndrome (APS).
Impact:
- Improved diagnostic accuracy for antiphospholipid syndrome (APS), potentially differentiating clinical entities.
- Enhanced understanding of the underlying mechanisms of APS, paving the way for targeted therapies.
- Evidence-based treatment strategies and algorithms for better patient management and outcomes in APS.
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