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Updated: Jun 15, 2026
10:14
Retroviral Transduction of T-cell Receptors in Mouse T-cells
Published on: October 22, 2010
[Receptors for animal retroviruses]
1Laboratory of Signal Transduction, Department of Cell Biology, Institute for Virus Research, Kyoto University, 53 Shogoin-Kawaracho, Sakyo-ku, Kyoto 606-8507, Japan. takavet@goo.jp
Uirusu
|March 12, 2010
Summary
Identifying animal retrovirus receptors is crucial for understanding disease, developing antiviral drugs, and advancing gene therapies. This review details known receptors for various veterinary retroviruses, aiding future research.
Area of Science:
- Veterinary Virology
- Molecular Biology
- Immunology
Context:
- Animal retroviruses cause significant diseases in livestock and companion animals.
- Understanding viral entry mechanisms is key to controlling infections and developing treatments.
- Receptor identification is essential for advancing gene therapy vectors.
Purpose:
- To provide a comprehensive overview of identified receptors for animal retroviruses.
- To highlight the importance of receptor discovery for pathogenesis and therapeutic development.
- To consolidate current knowledge on the molecular interactions of veterinary retroviruses.
Summary:
- This review summarizes known receptors for numerous veterinary retroviruses, including equine infectious anemia virus, feline immunodeficiency virus, and various avian leukosis viruses.
- It details receptor usage by different retroviral genera (Gammaretroviruses, Betaretroviruses, Alpharetroviruses) and specific examples like primate lentiviruses and feline immunodeficiency virus.
- The identified receptors often involve multi-spanning transmembrane proteins or GPI-anchored proteins, with some requiring co-receptors like CD4 and CXCR4.
Impact:
- Facilitates the development of targeted antiviral therapies and vaccines for animal retroviral diseases.
- Enables the design of safer and more efficient viral vectors for gene therapy in both animals and humans.
- Provides a foundational resource for researchers investigating retroviral pathogenesis and host-virus interactions.
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