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Trilostane in dogs
1Faculty of Veterinary Medicine, University of Glasgow, Bearsden, Bearsden Road Glasgow, Glasgow G61 1QH, UK. I.Ramsey@vet.gla.ac.uk
Summary
Trilostane effectively treats canine hyperadrenocorticism by lowering cortisol. Regular monitoring is crucial due to potential serious side effects, but most dogs show improved clinical signs.
Area of Science:
- Veterinary Medicine
- Endocrinology
- Pharmacology
Background:
- Canine hyperadrenocorticism is a common endocrine disorder.
- Trilostane is a widely used treatment for this condition.
- It acts as a competitive inhibitor of steroid synthesis.
Purpose of the Study:
- To review current knowledge on trilostane for canine hyperadrenocorticism.
- To emphasize efficacy, safety, and adverse reactions.
- To discuss effects on endocrine parameters and other uses.
Main Methods:
- Literature review of studies on trilostane in dogs.
- Analysis of efficacy, safety, and adverse event data.
- Examination of endocrine parameter changes and clinical outcomes.
Main Results:
- Trilostane significantly reduces cortisol production reversibly.
- Most dogs exhibit improved clinical signs of hyperadrenocorticism.
- Adverse effects are infrequent but can be serious, necessitating monitoring.
Conclusions:
- Trilostane is an effective treatment for canine hyperadrenocorticism.
- Careful patient monitoring is essential to manage potential side effects.
- The drug also has uses in other species and conditions.
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