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Updated: Jun 15, 2026
Mouse Models Of Helicobacter Infection And Gastric Pathologies
Published on: October 18, 2018
Helicobacter pullorum outbreak in C57BL/6NTac and C3H/HeNTac barrier-maintained mice
S R Boutin1, Z Shen, P L Roesch
1Taconic Inc., Hudson, New York 12534, USA.
Abstract:
Helicobacter pullorum is a bacterial pathogen in humans. By using microaerobic culture techniques, H. pullorum was isolated from the feces of barrier-maintained mice and identified, on the basis of biochemical, restriction fragment length polymorphism, and 16S rRNA gene sequence analyses. This finding presents an opportunity to study H. pullorum pathogenesis in mice.
Insights
Helicobacter pullorum, a human bacterial pathogen, was successfully isolated from mice feces. This discovery enables further research into H. pullorum
Area of Science:
- Microbiology
- Bacteriology
- Infectious Diseases
Background:
- Helicobacter pullorum is recognized as a bacterial pathogen capable of causing human infections.
- Understanding the transmission and pathogenesis of H. pullorum is crucial for public health.
Purpose of the Study:
- To isolate and identify Helicobacter pullorum from a non-human source.
- To establish a potential animal model for studying H. pullorum pathogenesis.
Main Methods:
- Microaerobic culture techniques were employed for bacterial isolation.
- Biochemical analyses were performed for identification.
- Restriction fragment length polymorphism (RFLP) was used for genetic characterization.
- 16S rRNA gene sequencing confirmed bacterial identity.
Main Results:
- Helicobacter pullorum was successfully isolated from the feces of barrier-maintained mice.
- Comprehensive analyses confirmed the presence and identity of H. pullorum.
Conclusions:
- The isolation of H. pullorum from mice provides a novel opportunity to investigate its pathogenesis in a controlled animal model.
- This finding may facilitate the development of new strategies for preventing and treating H. pullorum infections.
