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Updated: Jun 15, 2026
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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging
Akiko Shioiri1, Akeo Kurumaji, Takashi Takeuchi
1Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Japan.
Summary
White matter (WM) abnormalities and thalamus changes, often linked to aging, increase the risk of delirium after cardiac surgery. Semantic word fluency tests can help predict this condition.
Area of Science:
- Neuroscience
- Geriatrics
- Cardiology
Background:
- Delirium is a frequent and serious complication in elderly patients undergoing surgery.
- Identifying predictors of delirium is crucial for patient management.
Purpose of the Study:
- To investigate if white matter (WM) abnormalities, assessed by diffusion tensor imaging (DTI), predict delirium after cardiac surgery.
- To identify other risk factors for postoperative delirium.
Main Methods:
- 116 patients undergoing cardiac surgery were assessed using DTI for fractional anisotropy (FA) values before surgery.
- Pre-, peri-, and postoperative factors were evaluated.
- Delirium diagnosis followed DSM-IV criteria.
Main Results:
- 16.4% of patients developed delirium, predominantly those over 60.
- Advanced age and poor performance on semantic fluency tests predicted delirium.
- Lower FA values in deep WM and thalamus were observed in patients with delirium.
Conclusions:
- Aging-related abnormalities in deep WM and thalamus may increase vulnerability to postoperative delirium.
- Semantic word fluency is a potential predictive indicator for delirium.
