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Updated: Jun 15, 2026

A Preterm Rat Model for Pain Studies
Published on: February 9, 2024
Labor analgesia for patients with preterm premature rupture of membranes
M L Chichester1, M K Hoffman, G H C Colmorgen
1Department of Nursing, Labor and Delivery, Christiana Care Health Services, Newark, DE 19734, USA. mchichester@christianacare.org
Objective:
Cervical examination is relatively contraindicated in women with preterm premature rupture of membranes (PPROM), limiting our ability to determine the onset of labor by traditional definition (contractions with cervical change). We sought to determine whether two maternal requests for analgesia within 3 h predicted delivery within 24 h to allow appropriate epidural placement.
Study Design:
We performed a retrospective chart review of all patients with PPROM for a period of 18 months. Our primary outcome was the percentage of women with PPROM (<34 weeks) who delivered within 24 h from the second analgesia request.
Result:
Among women with PPROM, 63% delivered within 24 h from their second request for analgesia and 98% delivered within 48 h.
Conclusion:
Two medication requests within 3 h for regular, painful contractions can be used as an indicator of onset of labor in women with PPROM to allow for labor analgesia.
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