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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: Jun 15, 2026

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Exercise-induced hormesis may help healthy aging.

Li Li Ji1, Jonathan R Dickman, Chounghun Kang

  • 1The Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, 2000 Observatory Drive, Madison, WI 53706, USA. ji@education.wisc.edu

Dose-Response : a Publication of International Hormesis Society
|March 12, 2010
PubMed
Summary
This summary is machine-generated.

Exercise benefits stem from hormesis, a process where mild stress triggers adaptive responses. This study explores how antioxidant adaptation, mitochondrial biogenesis, and exercise-induced inflammation may promote healthy aging and improve muscle function.

Keywords:
agingexercisehormesismusclereactive oxygen species

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Published on: October 17, 2018

Area of Science:

  • Exercise physiology
  • Cellular adaptation
  • Aging research

Background:

  • Hormesis is crucial for exercise benefits.
  • Its role in mitigating age-related muscle decline is unclear.
  • Understanding these mechanisms can enhance healthy aging.

Purpose of the Study:

  • To investigate if known cellular hormetic mechanisms apply to age-related muscle dysfunction.
  • To propose exercise-induced redox-sensitive pathways that promote healthy aging.

Main Methods:

  • The study proposes theoretical pathways.
  • Focuses on antioxidant adaptation.
  • Examines peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha activated mitochondrial biogenesis.
  • Considers eccentric contraction-induced inflammation.

Main Results:

  • Exercise-induced disturbance in oxidant-antioxidant balance acts as a hormetic stimulus.
  • Antioxidant adaptation is a key redox-sensitive pathway.
  • PGC-1alpha activated mitochondrial biogenesis contributes to adaptation.
  • Cytokine-driven inflammation from eccentric contractions plays a role.

Conclusions:

  • Exercise-induced hormesis, via specific redox-sensitive pathways, can ameliorate age-related muscle deterioration.
  • These adaptations promote healthy aging and enhance quality of life.