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Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
Exercise-induced hormesis may help healthy aging
Li Li Ji1, Jonathan R Dickman, Chounghun Kang
1The Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, 2000 Observatory Drive, Madison, WI 53706, USA. ji@education.wisc.edu
Abstract:
Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha activated mitochondrial biogenesis, and eccentric contraction-induced, cytokine-propelled muscle inflammation could be important redox-sensitive pathways by which exercise-induced disturbance in oxidant-antioxidant hemeostasis may serve as a heretic stimulus to promote adaptations that help healthy aging and improve the quality of life.
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