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Updated: Jun 15, 2026

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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Design and efficient synthesis of a new scaffold based on unsymmetrical protoporphyrin IX derivatives for use in SPPS
1Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069 Faculté des Sciences et Techniques, 123 Avenue Albert Thomas, 87060 Limoges, France.
Abstract:
Fmoc-protected amine derivatives of Protoporphyrin IX were synthesized by two original methods using solid-phase chemistry. The new compounds represent unsymmetrical scaffolds suitable for the generation of a large range of peptidic porphyrin derivatives through SPPS strategy.

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