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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein and Protein Structures02:15

Protein and Protein Structures

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Protein structure databases.

Roman A Laskowski1

  • 1EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

Methods in Molecular Biology (Clifton, N.J.)
|March 12, 2010
PubMed
Summary
This summary is machine-generated.

Protein structure databases offer diverse resources, including structural atlases and fold classification systems. These tools aid in understanding protein function, evolution, and structural relationships for various research needs.

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Last Updated: Jun 15, 2026

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Area of Science:

  • Structural Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Web-based protein structure databases vary widely in type and information content.
  • General interest databases include structural atlases with 3D structure, function, and analysis links.
  • Fold classification databases are crucial for identifying evolutionary relationships beyond sequence analysis.

Purpose of the Study:

  • To provide an overview of the landscape of web-based protein structure databases.
  • To highlight the utility of different database types for researchers.
  • To categorize databases based on their primary function and user base.

Main Methods:

  • Review and categorization of existing web-based protein structure databases.
  • Analysis of information content and functionalities offered by various databases.
  • Identification of key features and applications for different user needs.

Main Results:

  • Identified structural atlases as key resources for experimentally determined protein structures.
  • Highlighted fold classification databases for evolutionary insights and structure comparison.
  • Noted specialized databases catering to specific research areas like protein families and diseases.

Conclusions:

  • Web-based protein structure databases are essential tools in modern biological research.
  • The diversity of databases supports various research levels, from general exploration to specialized analysis.
  • Effective utilization of these databases aids in understanding protein structure, function, and evolution.