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Updated: Jun 15, 2026

Detection and Isolation of Apoptotic Bodies to High Purity
12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

[Anti-apoptotic mechanisms in small-cell lung carcinoma]

Yohann Loriot1, Julien Calderaro, Jean-Charles Soria

  • 1Département de médecine, institut Gustave-Roussy, 39 rue Camille-Desmoulins, Villejuif, France. yohann.loriot@igr.fr

Annales De Pathologie
|March 13, 2010
PubMed

Insights

Small-cell lung cancer resists apoptosis due to altered molecular pathways, impacting treatment effectiveness. Identifying predictive factors is crucial for personalizing new therapies targeting these apoptosis-resistant mechanisms.

Area of Science:

  • Oncology and Molecular Biology
  • Cell Death Mechanisms

Context:

  • Small-cell lung cancer (SCLC) comprises 15-20% of lung malignancies.
  • SCLC exhibits inherent resistance to apoptosis, a key factor in treatment failure.
  • Dysregulation of apoptosis/antiapoptosis pathways contributes to chemo- and radioresistance in SCLC.

Purpose:

  • To elucidate the molecular mechanisms underlying apoptosis resistance in small-cell lung cancer.
  • To identify key molecular alterations in both intrinsic and extrinsic apoptosis pathways contributing to SCLC resistance.

Summary:

  • Alterations in mitochondrial pathways, including BCL2 and BCLXL overexpression and activation of HSP 90/70 and PI3K/AKT/mTOR, are implicated.
  • Inhibition of the extrinsic pathway, via caspase-8 and FAS underexpression or C-FLIP overexpression, also contributes to resistance.
  • These molecular aberrations present therapeutic targets for novel SCLC treatments.

Impact:

  • Highlights critical molecular targets for developing novel SCLC therapies.
  • Emphasizes the need for predictive biomarkers to personalize treatment strategies.
  • Advances understanding of apoptosis evasion in SCLC, paving the way for improved patient outcomes.

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