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Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Reproductive Cloning01:27

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...
Reproductive Cloning01:27

Reproductive Cloning

Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic cell—any cell that is not a sex...
Forced Transdifferentiation01:28

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial transdifferentiation occurs...
Cloning of Dolly the Sheep01:08

Cloning of Dolly the Sheep

The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter telomeres than other...

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Related Experiment Video

Updated: Jun 15, 2026

Enumeration of Neural Stem Cells Using Clonal Assays
10:32

Enumeration of Neural Stem Cells Using Clonal Assays

Published on: October 4, 2016

The Clara cell: a "Third Reich eponym"?

A Winkelmann1, T Noack

  • 1Institute of Cell Biology and Neurobiology, Center for Anatomy Charité - Universitätsmedizin Berlin, Schumannstr. 20/21, D-10117 Berlin, Germany. andreas.winkelmann@charite.de

The European Respiratory Journal
|March 13, 2010
PubMed
Summary
This summary is machine-generated.

Max Clara

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Last Updated: Jun 15, 2026

Enumeration of Neural Stem Cells Using Clonal Assays
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05:30

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Published on: March 13, 2011

Area of Science:

  • Pulmonary Medicine
  • Medical History
  • Bioethics

Background:

  • Max Clara (1899-1966), a German anatomist, described the Clara cell in 1937.
  • His career advancement was partly facilitated by support from the National Socialist regime.

Observation:

  • Clara was an active member of the Nazi party and made anti-Semitic remarks.
  • His histological research utilized tissue from executed prisoners.
  • This research included his original description of the bronchial epithelium.

Findings:

  • Clara's work was intrinsically linked to the Nazi system and its exploitation of executions.
  • His career was supported by Nazi patronage, despite also aiding persecuted colleagues.

Implications:

  • The findings necessitate a re-evaluation of the eponym "Clara cell".
  • This historical context raises ethical concerns regarding its continued use in medical terminology.
  • The problematic history of the eponym warrants critical discussion in scientific and medical communities.