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Updated: Aug 13, 2026

In vitro Labeling of Human Embryonic Stem Cells for Magnetic Resonance Imaging
Published on: August 3, 2008
Improved method for in vivo magnetic resonance contrast media research
U P Schmiedl1, K R Maravilla, J A Nelson
1Department of Radiology, University of Washington School of Medicine, Seattle 98195.
Abstract:
This paper describes an approach for contrast media research with which high resolution MR images of rats can be studied before, during, and after intravenous contrast media administration. Using a probe designed to hold up to eight rats, the contrast-enhancing properties in normal rat brains of Gd-DTPA, a low molecular weight compound, and polylysine-(Gd-DTPA), a high molecular weight compound, were compared simultaneously in two groups of four rats each. Signal intensity-time graphs, as measured over various anatomical structures of the normal rat head, demonstrated the feasibility of directly comparing enhancement patterns of two pharmacologically different contrast agents and obtaining relevant data in a single experiment.
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