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Related Experiment Video

Updated: Jun 15, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Nonfunctional parathyroid carcinoma.

Yosuke Nakamura¹, Hideyuki Kataoka, Takema Sakoda

¹Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, 683-8504, Japan. yosuken@med.tottori-u.ac.jp

International Journal of Clinical Oncology

|March 13, 2010

Summary

This case report details a rare instance of nonfunctional parathyroid carcinoma presenting as a large mediastinal mass. Despite imaging, the tumor was difficult to detect, highlighting diagnostic challenges in rare endocrine cancers.

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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

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Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

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Published on: August 17, 2022

Area of Science:

Endocrinology
Oncology
Pathology

Background:

Parathyroid carcinoma is a rare endocrine malignancy.
Nonfunctional variants present diagnostic challenges due to lack of hyperparathyroidism symptoms.

Observation:

A 65-year-old female presented with a large, painless superior mediastinal mass.
Imaging studies revealed a solid tumor, but Technetium (Tc-99) sestamibi scan showed a hypofunctioning area.
Preoperative diagnosis was uncertain, considering thyroid tumor or metastatic lymph node.

Findings:

Intraoperative frozen section suggested parathyroid carcinoma.
Histopathology confirmed parathyroid carcinoma with positive chromogranin A staining.
The tumor was negative for parathyroid hormone (PTH) immunostaining.

Implications:

This case underscores the possibility of nonfunctional parathyroid carcinoma presenting as a significant mediastinal mass.
Diagnostic modalities may fail to detect these rare tumors, necessitating high clinical suspicion.
Successful surgical resection and adjuvant radiotherapy led to a favorable long-term outcome without recurrence.