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Updated: Jun 15, 2026
09:34
Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
[Risperidone intoxication in a patient with a genetic predisposition as "poor [non]metabolizer"]
Maria Strauss1, Wolfram Heinritz, Ulrich Hegerl
1Department für psychische Gesundheit, Klinik und Poliklinik für Psychiatrie, Universität Leipzig, Leipzig. Maria.Strauss@medizin.unileipzig.de
Psychiatrische Praxis
|March 13, 2010
Summary
A patient experienced risperidone intoxication due to a genetic defect in the CYP2D6 enzyme, which is crucial for drug metabolism. This highlights the importance of considering enzyme function in psychoactive drug treatment.
Area of Science:
- Pharmacogenomics
- Drug Metabolism
- Enzyme Kinetics
Background:
- The cytochrome P450 system, particularly CYP2D6, is vital for metabolizing psychoactive medications.
- Genetic variations in CYP2D6 can significantly impair drug metabolism, leading to altered drug levels.
Observation:
- A 37-year-old female patient presented with risperidone intoxication despite a low dosage for acute delusional disorder.
- This suggested a potential metabolic disorder affecting drug plasma levels.
Findings:
- Molecular genetic analysis identified a compound heterozygous mutation in the CYP2D6 gene.
- This confirmed a genetic predisposition, classifying the patient as a poor metabolizer.
Implications:
- Enzyme defects within the P450 system should be considered in cases of psychoactive agent intoxication.
- Understanding individual metabolic capacity is crucial for safe and effective psychotropic drug prescribing.
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