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Src-like adaptor protein regulates osteoclast generation and survival

Hyun-Ju Kim1, Wei Zou, Yuji Ito

  • 1Department of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri 63110, USA. biohjk@knu.ac.kr

Journal of Cellular Biochemistry
|March 13, 2010
PubMed
Summary

Src-like adaptor protein (SLAP) negatively regulates osteoclast precursor proliferation and differentiation. While SLAP deficiency enhances osteoclast precursor proliferation, it also increases mature osteoclast apoptosis, leading to normal bone density.

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