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A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
Evolution of the Sequence Ontology terms and relationships
Christopher J Mungall1, Colin Batchelor, Karen Eilbeck
1Lawrence Berkeley National Laboratory, Mail Stop 64R0121, Berkeley, CA 94720, USA.
Journal of Biomedical Informatics
|March 16, 2010
Summary
The Sequence Ontology (SO) has been updated with new terms and relationships to improve the description of genomic and derived biological sequences. These enhancements facilitate better interoperability with other OBO Foundry ontologies.
Area of Science:
- Bioinformatics
- Genomics
- Ontology development
Background:
- The Sequence Ontology (SO) is a widely used resource for genomic annotation.
- Existing SO terms and relationships require enhancement for comprehensive biological sequence description.
Purpose of the Study:
- To reform the Sequence Ontology (SO) for improved genomic and derived sequence feature description.
- To enhance interoperability with other OBO Foundry ontologies.
Main Methods:
- Reforming the Sequence Ontology (SO).
- Developing new terms and relationships.
- Adhering to OBO Foundry guidelines for interoperability.
Main Results:
- Improved terms and relationships for describing biological sequence features.
- Enhanced mereological, spatial, and temporal aspects of biological sequence representation.
- Increased interoperability with other OBO Foundry ontologies.
Conclusions:
- The reformed Sequence Ontology (SO) offers a more robust framework for genomic annotation.
- Enhanced SO facilitates standardized description and integration of biological sequence data.
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