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Updated: Jun 15, 2026

Involving Individuals with Developmental Language Disorder and Their Parents/Carers in Research Priority Setting
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William H. Harridge Memorial Lecture: "Progress and its unintended consequences"

Jay L Grosfeld1

  • 1Section of Pediatric Surgery, Indiana University School of Medicine, and Riley Children's Hospital, Indianapolis, IN, USA. jgrosfeld@iupui.edu

American Journal of Surgery
|March 16, 2010
PubMed

Insights

Advances in neonatal and pediatric care improve survival but introduce new challenges. Long-term follow-up is crucial for managing unintended consequences in survivors of premature birth and childhood cancer.

Area of Science:

  • Pediatric Surgery
  • Neonatal Care
  • Pediatric Oncology

Background:

  • Significant clinical and technological advances have improved management of neonatal and childhood conditions.
  • Increased survival rates for infants and children have led to new, unintended health consequences.

Discussion:

  • Review of progress in pediatric surgical care for newborns and cancer patients.
  • Analysis of unintended consequences observed in survivors of these treatments.

Key Insights:

  • Premature infants show improved survival but higher risks of necrotizing enterocolitis, chronic lung disease, and neurodevelopmental issues.
  • Childhood cancer survivors face adverse sequelae from intensive therapies, including secondary neoplasms and multi-system effects.

Outlook:

  • While survival rates are remarkable, new challenges emerge from these medical advancements.
  • Modifications in patient care and long-term follow-up are essential for quality of life in survivors.
Abstract

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