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William H. Harridge Memorial Lecture: "Progress and its unintended consequences"
1Section of Pediatric Surgery, Indiana University School of Medicine, and Riley Children's Hospital, Indianapolis, IN, USA. jgrosfeld@iupui.edu
American Journal of Surgery
|March 16, 2010
Summary
Advances in neonatal and pediatric care improve survival but introduce new challenges. Long-term follow-up is crucial for managing unintended consequences in survivors of premature birth and childhood cancer.
Area of Science:
- Pediatric Surgery
- Neonatal Care
- Pediatric Oncology
Background:
- Significant clinical and technological advances have improved management of neonatal and childhood conditions.
- Increased survival rates for infants and children have led to new, unintended health consequences.
Discussion:
- Review of progress in pediatric surgical care for newborns and cancer patients.
- Analysis of unintended consequences observed in survivors of these treatments.
Key Insights:
- Premature infants show improved survival but higher risks of necrotizing enterocolitis, chronic lung disease, and neurodevelopmental issues.
- Childhood cancer survivors face adverse sequelae from intensive therapies, including secondary neoplasms and multi-system effects.
Outlook:
- While survival rates are remarkable, new challenges emerge from these medical advancements.
- Modifications in patient care and long-term follow-up are essential for quality of life in survivors.
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