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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...

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Related Experiment Video

Updated: Jun 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[Cutaneous, mucosal and systemic pyoderma gangrenosum].

C Poiraud1, V Gagey-Caron, S Barbarot

  • 1Clinique dermatologique, Hôtel-Dieu, CHU de Nantes, 44000 Nantes, France.

Annales De Dermatologie Et De Venereologie
|March 16, 2010
PubMed
Summary
This summary is machine-generated.

Pyoderma gangrenosum (PG) can rarely involve extracutaneous sites. This case highlights multifocal PG with systemic involvement, revealing underlying myelodysplastic syndrome in a patient with unusual oral lesions.

Related Experiment Videos

Last Updated: Jun 15, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Neutrophilic dermatoses rarely present with extracutaneous and mucosal involvement.
  • Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis characterized by ulcerative skin lesions.

Observation:

  • A 56-year-old man presented with an inflammatory abdominal plaque, fever, odynophagia, weight loss, and arthritis.
  • Examination revealed vegetative lesions on the lower lip and tongue, consistent with PG.
  • Systemic involvement included mesenteric panniculitis, interstitial lung disease, and myelodysplastic syndrome (MDS).

Findings:

  • Histological examination confirmed PG of the skin and mucosa.
  • Bone marrow biopsy revealed chronic myelomonocytic leukemia with myelofibrosis and high blast levels.
  • Systemic corticosteroids led to rapid resolution of cutaneous, mucosal, and visceral lesions.

Implications:

  • This case underscores the importance of considering systemic associations in atypical PG presentations.
  • Multifocal PG with unusual oral and extracutaneous involvement can be an early indicator of underlying hematologic malignancies like MDS.
  • Prompt diagnosis and treatment of the underlying MDS are crucial for managing severe PG cases.