A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial
M Katz1, A Adar Levine, H Kol-Degani
1ADHD and Adaptation Clinic, Sheba Medical Center, Tel Hashomer, Israel.
Objective:
Evaluation of the efficacy of a patented, compound herbal preparation (CHP) in improving attention, cognition, and impulse control in children with ADHD.
Design:
A randomized, double-blind, placebo-controlled trial.
Setting:
University-affiliated tertiary medical center.
Participants:
120 children newly diagnosed with ADHD, meeting DSM-IV criteria.
Intervention:
Random assignment to the herbal treatment group (n = 80) or control group (placebo; n = 40); 73 patients in the treatment group (91%) and 19 in the control group (48%) completed the 4-month trial.
Outcome Measure:
Test of Variables of Attention (TOVA) administered before and after the treatment period; overall score and 4 subscales.
Results:
The treatment group showed substantial, statistically significant improvement in the 4 subscales and overall TOVA scores, compared with no improvement in the control group, which persisted in an intention-to-treat analysis.
Conclusions:
The well-tolerated CHP demonstrated improved attention, cognition, and impulse control in the intervention group, indicating promise for ADHD treatment in children.
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