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Updated: Jun 15, 2026
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
Paraneoplastic syndromes and the kidney
Pedro Henrique de Oliveira Filgueira1, Leonardo Fernandes Vasconcelos, Geraldo Bezerra da Silva
1Department of Internal Medicine, Walter Cantidio University Hospital, Federal University of Ceara, Brazil. pedro_filgueira@hotmail.com
Summary
Paraneoplastic syndromes, triggered by cancer cells, can impair kidney function through various mechanisms. Early diagnosis and treatment of these renal syndromes are crucial for improving patient outcomes.
Area of Science:
- Nephrology
- Oncology
- Internal Medicine
Background:
- Paraneoplastic syndromes arise from substances released by cancer cells, affecting normal tissue function.
- Paraneoplastic renal syndromes indirectly impair kidney function via electrolyte disturbances, hormone secretion, or immune complex deposition.
- Understanding these syndromes is vital for managing cancer patients with renal complications.
Purpose of the Study:
- To review and describe common paraneoplastic syndromes affecting renal function.
- To highlight the mechanisms by which these syndromes compromise kidney health.
- To emphasize the importance of early diagnosis and treatment.
Main Methods:
- Extensive literature review of scientific publications.
- Inclusion of case reports, guidelines, and meta-analyses.
- Synthesis of information on paraneoplastic syndromes impacting renal function.
Main Results:
- Identified several paraneoplastic syndromes affecting renal function, including hypercalcemia in malignancies, syndrome of inappropriate antidiuretic hormone secretion, tumor lysis syndrome, renin-producing tumors, and paraneoplastic glomerulopathies.
- Detailed the indirect impact on tubular and glomerular function.
- Confirmed the diverse mechanisms of renal compromise.
Conclusions:
- Paraneoplastic syndromes represent a significant threat to renal function in cancer patients.
- Early identification and intervention are key to improving quality of life and prognosis.
- Further research and clinical awareness are needed to optimize patient care.
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