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Published on: October 11, 2014
Histoplasmosis in kidney transplant recipients
Osvaldo Mariano Viana Neto1, Matheus Alves de Lima Mota2,3,4, Pedro Yago Lima Mesquita1
1Walter Cantídio University Hospital, Federal University of Ceará, Fortaleza, Ceará, Brazil.
BMC Nephrology
|July 7, 2026
Summary
Histoplasma capsulatum var. capsulatum causes progressive disseminated histoplasmosis (PDH), a severe systemic illness. This review focuses on PDH in kidney transplant recipients, detailing its rare occurrence, complications like acute kidney injury, and management strategies.
Area of Science:
- Mycology
- Infectious Diseases
- Immunology
Background:
- Histoplasma capsulatum var. capsulatum is a dimorphic fungus causing disease dependent on host immunity.
- Progressive disseminated histoplasmosis (PDH) is severe in immunocompromised individuals, presenting diverse symptoms.
- While common in AIDS patients, PDH is rare but serious in kidney transplant (KT) recipients.
Purpose of the Study:
- To review key aspects of PDH in KT recipients.
- To cover epidemiology, pathophysiology, clinical features, and diagnostics.
- To discuss AKI, treatment, and prophylaxis in this specific population.
Main Methods:
- Literature review of PDH in KT recipients.
- Synthesis of epidemiological data.
- Analysis of clinical presentations and diagnostic challenges.
Main Results:
- PDH in KT recipients is rare but carries significant risks, including AKI and graft loss.
- Symptoms are diverse, complicating diagnosis.
- Treatment and prophylaxis strategies are crucial for managing this infection.
Conclusions:
- PDH is an uncommon yet severe complication in KT recipients.
- Early diagnosis and comprehensive management are vital.
- Further research into optimal treatment and prevention is warranted.
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