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Interstitial chemotherapy for brain tumors: review
1Division of Pediatric Neurosurgery, Children's Memorial Hospital, Chicago, Illinois.
Journal of Neuro-Oncology
|February 1, 1991
Summary
Interstitial chemotherapy offers a promising approach for malignant brain tumors, delivering drugs directly to the tumor. This method shows limited toxicity and encouraging efficacy, warranting further investigation for brain cancer treatment.
Area of Science:
- Neuro-oncology
- Pharmacology
- Drug Delivery Systems
Background:
- Malignant brain tumors lack effective systemic chemotherapeutic breakthroughs.
- Systemic chemotherapy shows limited clinical response and significant toxicity.
- Interstitial chemotherapy bypasses the blood-brain barrier, enhancing drug concentration at the tumor site.
Purpose of the Study:
- To review the literature on interstitial chemotherapy for malignant brain tumors.
- To identify methods, toxicity, and efficacy of interstitial chemotherapy.
- To explore the potential of interstitial chemotherapy as a treatment for fatal brain cancers.
Main Methods:
- Literature review of clinical and experimental data on interstitial chemotherapy.
- Analysis of various administration methods: intraoperative topical application, catheter injections, and implantable drug delivery systems.
Main Results:
- Interstitial chemotherapy demonstrates limited toxicity.
- Clinical and experimental data suggest promising efficacy for malignant brain tumors.
- Multiple administration methods have been utilized, including topical, injection, and controlled release systems.
Conclusions:
- Interstitial chemotherapy presents a viable strategy for managing malignant brain tumors.
- Further research is needed to optimize chemotherapeutic agent selection and drug delivery systems.
- This approach holds promise for improving outcomes in patients with otherwise fatal brain cancers.