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Transcription factor ZBP-89 in cancer growth and apoptosis

Chris Z Y Zhang1, George G Chen, Paul B S Lai

  • 1Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong.

Biochimica Et Biophysica Acta
|March 17, 2010
PubMed

Insights

Zinc-binding protein 89 (ZBP-89) regulates cell growth and death, impacting cancer cell proliferation and apoptosis. Overexpressed ZBP-89 in human cancers offers a potential therapeutic target for cancer treatment.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • ZBP-89 is a Krüppel-type zinc-finger transcription factor regulating cell growth and death.
  • It interacts with key cell cycle regulators like p53 and p21(waf1).

Purpose of the Study:

  • To investigate the role of ZBP-89 in cell proliferation, apoptosis, and cancer.
  • To explore ZBP-89 as a potential therapeutic target in cancer therapy.

Main Methods:

  • Analysis of ZBP-89's interactions with p53 and p21(waf1).
  • Assessment of ZBP-89's effect on gene expression (e.g., p16, vimentin).
  • Evaluation of ZBP-89's role in cancer cell apoptosis and drug sensitivity.

Main Results:

  • ZBP-89 stabilizes p53, enhances its nuclear retention and transcriptional activity.
  • It potentiates butyrate-induced p21(waf1) up-regulation.
  • Overexpressed ZBP-89 induces apoptosis via p53-dependent and -independent pathways and enhances anti-cancer drug efficacy.

Conclusions:

  • ZBP-89 plays a critical role in cell cycle regulation and apoptosis.
  • Its overexpression in cancer suggests ZBP-89 is a promising therapeutic target for novel cancer treatments.

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