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Primary hyperparathyroidism with brown tumor mimicking metastatic bone malignancy
Alvin W Su1, Cheng-Fong Chen, Ching-Kuei Huang
1Department of Orthopedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, R.O.C.
Journal of the Chinese Medical Association : JCMA
|March 17, 2010
Summary
Brown tumors, a rare manifestation of parathyroid adenoma, can mimic bone metastases. Surgical removal of the adenoma resolved the brown tumors and bone pain, highlighting the importance of considering metabolic bone disease.
Area of Science:
- Endocrinology
- Oncology
- Orthopedics
Background:
- Metastatic bone tumor is often the primary consideration for osteolytic lesions in the elderly.
- Differential diagnoses for bone lesions include metabolic bone diseases.
Observation:
- A patient presented with diffuse bone pain and multiple osteolytic lesions, initially suggestive of metastatic bone tumor.
- The patient's condition was diagnosed as a brown tumor secondary to parathyroid adenoma.
Findings:
- Surgical excision of the parathyroid adenoma was the definitive treatment.
- Post-surgery, normalization of serum intact-parathyroid hormone levels led to the resolution of bony lesions.
Implications:
- Clinicians should consider brown tumors as a differential diagnosis for osteolytic bone lesions.
- Awareness of metabolic bone disease is crucial for accurate diagnosis and management of bone pain.
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