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Arginine methylation of the B cell antigen receptor promotes differentiation

Simona Infantino1, Beate Benz, Tanja Waldmann

  • 1Center for Biological Signaling Studies, Faculty of Biology, Albert-Ludwigs-University of Freiburg, 79104 Freiburg, Germany.

The Journal of Experimental Medicine
|March 17, 2010
PubMed

Signals processed through the B cell antigen receptor (BCR) control both the proliferation and differentiation of B lymphocytes. How these different signaling modes are established at the BCR is poorly understood. We show that a conserved arginine in the tail sequence of the Igalpha subunit of the BCR is methylated by the protein arginine methyltransferase 1. This modification negatively regulates the calcium and PI-3 kinase pathways of the BCR while promoting signals leading to B cell differentiation. Thus, Igalpha arginine methylation can play an important role in specifying the outcome of BCR signaling.

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