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Updated: Jun 15, 2026

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
Published on: May 6, 2014
[Role of histamine in atherosclerotic lesions]
Ke-Yong Wang1, Akihide Tanimoto, Yasuyuki Sasaguri
1Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Japan.
Abstract:
Histamine is synthesized from L-histidine by histidine decarboxylase and is involved in a variety of physiologic responses, such as inflammation, type I allergy, gastric acid secretion and neurotransmission. In the arteriosclerotic lesions, histamine produced by macrophage-derived foam cells acts on smooth muscle cells, endocrine cells and inflammation cells through the specific histamine receptors and regulates the expression of many molecules concerned with inflammatory reaction. A regulatory system of chronic inflammatory reaction by the histamine network is involved in the formation and development of arteriosclerosis.
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