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Related Concept Videos

Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.

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Related Experiment Video

Updated: Jun 15, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

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Published on: March 8, 2019

Thiol-containing degradable poly(thiourethane-urethane)s for tissue engineering.

David Eglin1, Stéphane Griffon, Mauro Alini

  • 1AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos Platz, Switzerland. david.eglin@aofoundation.org

Journal of Biomaterials Science. Polymer Edition
|March 18, 2010
PubMed
Summary
This summary is machine-generated.

New biodegradable poly(thiourethane-urethane)s were synthesized for tissue engineering. These materials feature surface thiol groups, enhancing biocompatibility and enabling further functionalization for improved biological activity compared to traditional polyurethanes.

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Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
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Published on: August 1, 2018

Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Biodegradable polymers are crucial for tissue engineering applications.
  • Conventional biodegradable polyurethanes often exhibit limited biological activity.
  • Surface functionalization is key to enhancing biomaterial performance.

Purpose of the Study:

  • To synthesize novel poly(thiourethane-urethane)s with tunable sulfur content.
  • To characterize the physical, chemical, and surface properties of the synthesized polymers.
  • To evaluate the potential of these polymers for cartilage and bone tissue engineering.

Main Methods:

  • Two-step polycondensation using 1,6-hexamethylene diisocyanate and bis(2-mercaptoethyl) ether.
  • Size-exclusion chromatography and thermal analysis for polymer characterization.
  • X-ray photoelectron spectroscopy, atomic force microscopy, and fluorescent assays for surface analysis.

Main Results:

  • Polymers exhibited high molecular weight and microdomain separation.
  • Surface thiol group concentration ranged from 7 to 14 nmol/cm.
  • Thiol concentration correlated with sulfur content and chain orientation.
  • Preliminary in vitro studies showed promising degradation and cell proliferation.

Conclusions:

  • Synthesized poly(thiourethane-urethane)s are suitable for tissue engineering.
  • Surface thiol groups offer opportunities for further biomaterial functionalization.
  • These novel polymers present enhanced biocompatibility and biological activity compared to conventional polyurethanes.