Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 15, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Exploring melanoma's massively parallel universe.

Keith S Hoek1

  • 1keith.hoek@usz.ch

Pigment Cell & Melanoma Research
|March 19, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A purine nucleotide biosynthesis enzyme guanosine monophosphate reductase is a suppressor of melanoma invasion.

Cell reports·2013
Same author

Hypoxia contributes to melanoma heterogeneity by triggering HIF1α-dependent phenotype switching.

The Journal of investigative dermatology·2013
Same author

E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells.

Pigment cell & melanoma research·2013
Same author

Systematic classification of melanoma cells by phenotype-specific gene expression mapping.

Pigment cell & melanoma research·2012
Same author

GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells.

Pigment cell & melanoma research·2011
Same author

Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching.

Pigment cell & melanoma research·2011
Same journal

Comparison of Human Melanoma Single Cell Profiles to Evolutionary Medicine Model Xiphophorus Provides Insights in Disease Control.

Pigment cell & melanoma research·2026
Same journal

Genome-Wide Association Study of Nevus Count Reveals Opposing Effects of Genetic Loci Near IRF4 and MC1R on Flat Versus Raised Nevus Count in the Brisbane Twin Nevus Study: A Cross-Sectional Analysis.

Pigment cell & melanoma research·2026
Same journal

Revisiting Stability: The Missing Therapeutic Endpoint in Active Vitiligo Trials.

Pigment cell & melanoma research·2026
Same journal

Multi-Omics Identifies CTSS as a Susceptibility Gene and Actionable Target That Regulates Melanocyte MHC-II Expression and Survival in Vitiligo.

Pigment cell & melanoma research·2026
Same journal

Meeting Report From the 2025 Cure Ocular Melanoma (CURE OM) Global Science Meeting, Amsterdam, the Netherlands, October 2025.

Pigment cell & melanoma research·2026
Same journal

Pegargiminase Suppresses the Fanconi Anemia Pathway and Promotes Melphalan-Induced DNA Double-Strand Breaks in Uveal Melanoma.

Pigment cell & melanoma research·2026
See all related articles

This study presents an integrative analysis of the melanoma transcriptome, identifying key genes and pathways involved in melanoma development. The findings offer insights into melanoma biology and potential therapeutic targets.

Area of Science:

  • Genomics
  • Oncology
  • Bioinformatics

Background:

  • Melanoma is a significant form of skin cancer with complex genetic underpinnings.
  • Understanding the melanoma transcriptome is crucial for identifying drivers of tumorigenesis and progression.

Purpose of the Study:

  • To perform an integrative analysis of the melanoma transcriptome.
  • To identify novel genes and molecular pathways implicated in melanoma.

Main Methods:

  • Utilized transcriptomic data from melanoma samples.
  • Employed integrative bioinformatics approaches to analyze gene expression patterns.

Main Results:

  • Identified a set of genes significantly altered in melanoma.
  • Discovered distinct molecular subtypes within melanoma based on transcriptome profiles.

More Related Videos

DNA-barcode-based Multiplex Immunofluorescence Imaging to Analyze FFPE Specimens from Genetically Reprogrammed Murine Melanoma
09:58

DNA-barcode-based Multiplex Immunofluorescence Imaging to Analyze FFPE Specimens from Genetically Reprogrammed Murine Melanoma

Published on: June 6, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Related Experiment Videos

Last Updated: Jun 15, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

DNA-barcode-based Multiplex Immunofluorescence Imaging to Analyze FFPE Specimens from Genetically Reprogrammed Murine Melanoma
09:58

DNA-barcode-based Multiplex Immunofluorescence Imaging to Analyze FFPE Specimens from Genetically Reprogrammed Murine Melanoma

Published on: June 6, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

  • Highlighted specific signaling pathways dysregulated in melanoma progression.

    • Conclusions:

    • The integrative transcriptome analysis provides a comprehensive view of melanoma molecular landscape.
    • Key genes and pathways identified may serve as biomarkers or therapeutic targets for melanoma treatment.