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Related Experiment Video

Updated: Jun 15, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Central nervous system involvement in diffuse large B-cell lymphoma.

Wataru Yamamoto¹, Naoto Tomita, Reina Watanabe

¹Department of Hematology, Yamato Municipal Hospital, Yamato, Japan.

European Journal of Haematology

|March 19, 2010

Summary

Central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) remains a risk despite rituximab. This study identified no significant predictors for CNS involvement in the rituximab era, indicating a need for further research.

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Last Updated: Jun 15, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Area of Science:

Hematology
Oncology
Clinical Research

Background:

Malignant lymphoma involving the central nervous system (CNS) is associated with a very poor prognosis.
Diffuse large B-cell lymphoma (DLBCL) is a common type of non-Hodgkin lymphoma.
Understanding risk factors for CNS involvement is crucial for improving patient outcomes.

Purpose of the Study:

To identify risk factors for CNS involvement in DLBCL patients.
To evaluate the impact of rituximab on CNS involvement rates.

Main Methods:

Retrospective study of 375 newly diagnosed DLBCL patients (1996-2006).
Patients receiving CHOP or rituximab-CHOP chemotherapy were analyzed.
Variables assessed included demographics, clinical stage, LDH, IPI, and treatment, excluding primary CNS involvement or prophylaxis.

Main Results:

CNS involvement occurred in 3.5% of patients.
Univariate analysis showed LDH, high IPI, bone marrow involvement, and systemic relapse as predictors.
Multivariate analysis revealed no significant risk factors; rituximab did not impact CNS involvement.

Conclusions:

The incidence of CNS involvement in DLBCL has not decreased with the introduction of rituximab.
Further research is needed to identify effective strategies for CNS prophylaxis or treatment in DLBCL.