Relation between optic nerve axon number and axon diameter to scleral canal area

To determine whether there are more axons present in eyes with larger optic discs, the authors studied 16 eyes from 16 individuals whose eyes were donated for corneal transplantation. For each nerve, the axon count, axon diameter, and scleral canal area was measured. Total axon count decreased with age. Mean axon diameter increased with age. There was no statistically significant relation detected between axon count and scleral canal area. Multiple regression revealed that when corrected for the effect of age, eyes with smaller scleral canal areas had larger number of axons.