Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Urine and cerebrospinal fluid biomarkers for early glioma detection: a systematic review.

Diagnostic and prognostic research·2026
Same author

An essential medicines list in Ireland: A qualitative interview study of interest-holders.

Health policy (Amsterdam, Netherlands)·2026
Same author

Gabapentinoids and unexplained death in general practice: Case series and feasibility study arising from a critical incident.

The European journal of general practice·2026
Same author

Characterising prescribing cascades in older community-dwelling adults attending general practice in The Netherlands: a retrospective cohort study.

BMC primary care·2026
Same author

Associations between pharmaceutical industry interactions with physicians and chronic nonmalignant pain management prescribing practices: a systematic review.

Cost effectiveness and resource allocation : C/E·2026
Same author

Interventions to promote patient utilisation of cardiac rehabilitation.

The Cochrane database of systematic reviews·2026

Related Experiment Video

Updated: Jun 15, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Interventions to improve adherence to lipid lowering medication.

Angela Schedlbauer1, Philippa Davies, Tom Fahey

  • 1Division of Primary Care, School of Community Health Studies, University of Nottingham, Nottingham, UK, NG7 2RD.

The Cochrane Database of Systematic Reviews
|March 19, 2010
PubMed
Summary

Reminding patients to take lipid-lowering drugs is the most effective intervention for improving adherence. This systematic review highlights that patient reinforcement and reminding strategies significantly increase medication adherence, crucial for cardiovascular disease prevention.

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Related Experiment Videos

Last Updated: Jun 15, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Lipid-lowering drugs are underutilized for cardiovascular disease (CVD) prevention.
  • Poor patient adherence is a primary barrier to effective hyperlipidemia management.
  • This review focuses on interventions to improve adherence to lipid-lowering medications.

Purpose of the Study:

  • To evaluate interventions designed to enhance patient adherence to lipid-lowering drugs.
  • To assess the impact of these interventions on adherence rates and clinical outcomes.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) published up to March 2008.
  • Searched multiple databases including CENTRAL, MEDLINE, EMBASE, PsycINFO, and CINAHL.
  • Included studies on adults in ambulatory settings for primary and secondary CVD prevention.

Main Results:

  • Eleven studies were included, with adherence changes ranging from -3% to +25%.
  • Patient reinforcement and reminding interventions showed the most promise, with statistically significant adherence increases (up to 24%).
  • Simplifying drug regimens and patient education also improved adherence (11% and 13% increases, respectively).

Conclusions:

  • Patient reminding strategies appear most effective for increasing adherence to lipid-lowering medications.
  • Challenges in adherence research include the lack of a gold standard measurement method and short follow-up periods.
  • Future research should focus on reliable measurement, longer follow-up, and patient-centered approaches like shared decision-making.