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Related Experiment Videos

Equine chorionic gonadotropin.

B D Murphy1, S D Martinuk

  • 1Department of Obstetrics and Gynecology, University of Saskatchewan, Saskatoon, Canada.

Endocrine Reviews
|February 1, 1991
PubMed
Summary
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Equine chorionic gonadotropin (eCG) from endometrial cups is heavily glycosylated, conferring a long half-life. This hormone exhibits unique dual FSH and LH activity in non-equine species, with its exact role in horse pregnancy still under investigation.

Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Glycoprotein Hormone Research

Background:

  • Equine trophoblast cells form endometrial cups during gestation.
  • These cups produce chorionic gonadotropin (CG), a glycoprotein hormone present in maternal circulation.
  • Horse CG (eCG) is well-characterized compared to donkey CG.

Purpose of the Study:

  • To detail the structure and function of equine chorionic gonadotropin (eCG).
  • To investigate the unique cross-species activity of eCG.
  • To explore the role of eCG in equine pregnancy.

Main Methods:

  • Biochemical characterization of eCG structure, including subunits and glycosylation.
  • In vitro bioassays and receptor binding studies to assess hormonal activity.

Related Experiment Videos

  • Analysis of eCG presence and potential function during equine gestation.

    • Main Results:

    • eCG is a heavily glycosylated glycoprotein hormone with alpha and beta subunits.
    • It possesses a long circulatory half-life due to sialic acid residues.
    • eCG exhibits potent LH-like activity in horses and significant FSH and LH activity in other mammalian species, binding to both FSH and LH receptors.

    Conclusions:

    • Equine CG's unique glycosylation pattern contributes to its extended half-life.
    • The hormone's cross-species receptor binding and biological activity are notable but structurally unexplained.
    • The precise necessity of eCG and accessory corpora lutea for maintaining successful equine pregnancy requires further elucidation.