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L-669,262, a potent HMG-CoA reductase inhibitor
H Joshua1, M S Schwartz, K E Wilson
1Merck Sharp & Dohme Research Laboratories, Inc., Rahway, NJ 07065.
The Journal of Antibiotics
|March 1, 1991
Abstract:
The microbial transformation of simvastatin (MK-733) by Nocardia autotrophica subspecies amethystina yielded iso-simvastatin-6-one as a minor component. This transformation product is a dienone and is one of the more potent inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase found to date.