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Reinke's oedema and thyroid function.

A White1, D W Sim, A G Maran

  • 1Department of Otolaryngology, Royal Infirmary, Edinburgh.

The Journal of Laryngology and Otology
|April 1, 1991
PubMed
Summary

This study investigated the link between Reinke's oedema (RO) and hypothyroidism. Researchers found no significant difference in hypothyroidism rates between RO patients and controls, suggesting it is not a cause of RO.

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Area of Science:

  • Otolaryngology
  • Endocrinology
  • Vocal Fold Pathology

Background:

  • Reinke's oedema (RO) is a vocal fold condition with unknown causes.
  • Cigarette smoking and vocal abuse are suspected contributors.
  • Hypothyroidism has been anecdotally linked to RO, but lacks controlled study evidence.

Purpose of the Study:

  • To prospectively compare thyroid function in Reinke's oedema patients versus a control group.
  • To determine if hypothyroidism is an aetiological factor in Reinke's oedema development.

Main Methods:

  • A prospective, controlled study involving 61 RO patients and 65 age/sex-matched controls.
  • Thyroid function assessed via serum TSH, free T4, and T3 levels.
  • Hypothyroidism defined by elevated TSH with low T3 and T4.

Main Results:

  • Hypothyroidism incidence was similar between RO patients (4/61) and controls (5/65).
  • Past or present hypothyroidism was also comparable between groups (6/61 RO vs. 7/65 controls).
  • Marginally elevated TSH levels were observed in one RO patient and two controls.

Conclusions:

  • The prevalence of hypothyroidism in Reinke's oedema patients is not significantly higher than in the general population.
  • Findings suggest hypothyroidism is unlikely to be an aetiological factor in Reinke's oedema.
  • Observed rates align with hypothyroidism prevalence in middle-aged women.

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